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1

Drug–target residence time and its implications for lead optimization

Copeland, Robert A., Pompliano, David L., Meek, Thomas D.

Journal:

Nature Reviews Drug Discovery

Year:

2006

Language:

english

File:

PDF, 454 KB

english, 2006

2

A Multitarget Assay for Inhibitors of Membrane-Associated Steps of Peptidoglycan Biosynthesis

Maria D.F.S. Barbosa, Harold O. Ross, Milton C. Hillman, Raymond P. Meade, Michael G. Kurilla, David L. Pompliano

Journal:

Analytical Biochemistry

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

3

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Payne, David J., Gwynn, Michael N., Holmes, David J., Pompliano, David L.

Journal:

Nature Reviews Drug Discovery

Year:

2006

Language:

english

File:

PDF, 441 KB

english, 2006

4

Drug–target residence time and its implications for lead optimization

Copeland, Robert A., Pompliano, David L., Meek, Thomas D.

Journal:

Nature Reviews Drug Discovery

Year:

2007

Language:

english

File:

PDF, 82 KB

english, 2007

5

ChemInform Abstract: Potent, Non-Thiol Inhibitors of Farnesyltransferase.

Michael J. Breslin, S. Jane deSolms, Elizabeth A. Giuliani, Gerald E. Stokker, Samuel L. Graham, David L. Pompliano, Scott D. Mosser, Hamilton Kelly A. Hamilton Kelly A., John H. Hutchinson

Journal:

Year:

1999

File:

PDF, 27 KB

1999

6

Soluble Penicillin-Binding Protein 2a: β-Lactam Binding and Inhibition by Non-β-Lactams Using a 96-Well Format

Jeffrey H. Toney, Gail G. Hammond, Barbara Leiting, KellyAnn D. Pryor, Joseph K. Wu, Gregory C. Cuca, David L. Pompliano

Journal:

Analytical Biochemistry

Year:

1998

Language:

english

File:

PDF, 169 KB

english, 1998

7

A Continuous Fluorometric Assay of Myristoyl-Coenzyme A:Protein N-Myristoyltransferase

Cynthia R. Pennise, Nafsika H. Georgopapadakou, R.Dale Collins, Nilsa R. Graciani, David L. Pompliano

Journal:

Analytical Biochemistry

Year:

2002

Language:

english

File:

PDF, 49 KB

english, 2002

8

PolC-Type Polymerase III of Streptococcus pyogenes and Its Use in Screening for Chemical Inhibitors

Fude Yang, Ira B. Dicker, Michael G. Kurilla, David L. Pompliano

Journal:

Analytical Biochemistry

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

9

Homogenous Assays for Escherichia coli DnaB-Stimulated DnaG Primase and DnaB Helicase and Their Use in Screening for Chemical Inhibitors

Yi Zhang, Fude Yang, Yeh-Chih Kao, Michael G. Kurilla, David L. Pompliano, Ira B. Dicker

Journal:

Analytical Biochemistry

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

10

Cloning, expression and characterization of the Streptococcus pyogenes murE gene encoding a UDP-MurNAc-l-alanyl-d-glutamate: l-lysine ligase

Thomas A Triolo, Renee M Chabin, David L Pompliano

Journal:

Enzyme and Microbial Technology

Year:

2004

Language:

english

File:

PDF, 249 KB

english, 2004

11

Biotechnology: Paper alert

Tony Cass, Jim Dunwell, Lawrence P Wackett, Gianfranco Gilardi, Thomas Kost, David L Pompliano

Journal:

Current Opinion in Biotechnology

Year:

1999

Language:

english

File:

PDF, 72 KB

english, 1999

12

Potent, non-thiol inhibitors of farnesyltransferase

Michael J. Breslin, S.Jane deSolms, Elizabeth A. Giuliani, Gerald E. Stokker, Samuel L. Graham, David L. Pompliano, Scott D. Mosser, Kelly A. Hamilton, John H. Hutchinson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 258 KB

english, 1998

13

Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase

Mark L. Greenlee, Joanne B. Laub, James M. Balkovec, Milton L. Hammond, Gail G. Hammond, David L. Pompliano, Jeffrey H. Epstein-Toney

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 408 KB

english, 1999

14

Synthesis and biological activity of ras farnesyl protein transferase inhibitors. Tetrapeptide analogs with amino methyl and carbon linkages

John S. Wai, Dona L. Bamberger, Thorsten E. Fisher, Samuel L. Graham, Robert L. Smith, Jackson B. Gibbs, Scott D. Mosser, Allen I. Oliff, David L. Pompliano, Elaine Rands, Nancy E. Kohl

Journal:

Bioorganic & Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 954 KB

english, 1994

15

Next-generation therapeutics

Gary D. Glick, David L. Pompliano

Journal:

Current Opinion in Chemical Biology

Year:

2002

Language:

english

File:

PDF, 35 KB

english, 2002

16

Chemical biology: Paper alert

Dale Drueckhammer, Richard Cammack, David L Pompliano, Tony Cass, Jon D Stewart, Graham R.L Cousins, Yolanda R de Miguel, Jeremy K.M Sanders, Sabine Flitsch, Philip A.S Lowden, Gary J Pielak

Journal:

Current Opinion in Chemical Biology

Year:

1999

Language:

english

File:

PDF, 78 KB

english, 1999

17

Biotechnology

Tony Cass, Jim Dunwell, Lawrence P Whackett, Gianfranco Gilardi, Thomas Kost, Patrick Condreay, David L Pompliano

Journal:

Current Opinion in Biotechnology

Year:

1999

Language:

english

File:

PDF, 84 KB

english, 1999

18

Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives

Gail G. Hammond, Joann L. Huber, Mark L. Greenlee, Joanne B. Laub, Katherine Young, Lynn L. Silver, James M. Balkovec, KellyAnn D. Pryor, Joseph K. Wu, Barbara Leiting, David L. Pompliano, Jeffrey H.

Journal:

FEMS Microbiology Letters

Year:

1999

Language:

english

File:

PDF, 316 KB

english, 1999

19

Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus

Scott J. POLLACK, Sally FREEMAN, David L. POMPLIANO, Jeremy R. KNOWLES

Journal:

Year:

1992

Language:

english

File:

PDF, 940 KB

english, 1992

20

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

Kohl, N., Mosser, S., deSolms, S., Giuliani, E., Pompliano, D., Graham, S., Smith, R., Scolnick, E., Oliff, A, Gibbs, J.

Journal:

Year:

1993

Language:

english

File:

PDF, 1.28 MB

english, 1993

21

High-Yield Expression, Purification, and Characterization of Active, SolubleBacteroides fragilisMetallo-β-Lactamase, CcrA

Jeffrey H. Toney, Joseph K. Wu, Karen M. Overbye, Chris M. Thompson, David L. Pompliano

Journal:

Protein Expression and Purification

Year:

1997

Language:

english

File:

PDF, 314 KB

english, 1997

22

Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives

Gail G. Hammond, Joann L. Huber, Mark L. Greenlee, Joanne B. Laub, Katherine Young, Lynn L. Silver, James M. Balkovec, KellyAnn D. Pryor, Joseph K. Wu, Barbara Leiting, David L. Pompliano, Jeffrey H.

Journal:

FEMS Microbiology Letters

Year:

1999

Language:

english

File:

PDF, 319 KB

english, 1999

23

Cloning and expression of Staphylococcus aureus and Streptococcus pyogenes murD genes encoding uridine diphosphate N-acetylmuramoyl-l-alanine:d-glutamate ligases

Mohamed El-Sherbeini, Wayne M. Geissler, Jamya Pittman, Xiling Yuan, Kenny K. Wong, David L. Pompliano

Journal:

Year:

1998

Language:

english

File:

PDF, 623 KB

english, 1998

24

Anti-infective research and development—problems, challenges, and solutions

John S Bradley, Robert Guidos, Steve Baragona, John G Bartlett, Ethan Rubinstein, George G Zhanel, Michael D Tino, David L Pompliano, Frank Tally, Praveen Tipirneni, Glenn S Tillotson, John H Powers,

Journal:

The Lancet Infectious Diseases

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

25

Kinetic Mechanism of the Escherichia coli UDPMurNAc-Tripeptide d -Alanyl- d -alanine-Adding Enzyme: Use of a Glutathione S -Transferase Fusion

Anderson, Matt S., Eveland, Suzanne S., Onishi, H. Russell, Pompliano, David L.

Journal:

Year:

1996

Language:

english

File:

PDF, 363 KB

english, 1996

26

Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase

Pompliano, David L., Peyman, Anusch, Knowles, Jeremy R.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.79 MB

english, 1990

27

Biocatalytic synthesis of aromatics from D-glucose: the role of transketolase

Draths, K. M., Pompliano, D. L., Conley, D. L., Frost, J. W., Berry, A., Disbrow, G. L., Staversky, R. J., Lievense, J. C.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 1.26 MB

english, 1992

28

Conditionally Lethal Escherichia coli Murein Mutants Contain Point Defects That Map to Regions Conserved among Murein and Folyl Poly-γ-glutamate Ligases: Identification of a Ligase Superfamily

Eveland, Suzanne S., Pompliano, David L., Anderson, Matt S.

Journal:

Year:

1997

Language:

english

File:

PDF, 353 KB

english, 1997

29

Phosphonate biosynthesis: molecular cloning of the gene for phosphoenolpyruvate mutase from Tetrahymena pyriformis and overexpression of the gene product in Escherichia coli

Seidel, H. Martin, Pompliano, David L., Knowles, Jeremy R.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.38 MB

english, 1992

30

Steady-state kinetic mechanism of ras farnesyl:protein transferase

Pompliano, David L., Rands, Elaine, Schaber, Michael D., Mosser, Scott D., Anthony, Neville J., Gibbs, Jackson B.

Journal:

Year:

1992

Language:

english

File:

PDF, 2.19 MB

english, 1992

31

1010-62 Impact of Breast Repositioning in Women on SPECT Thallium-201 Myocardial Perfusion Imaging

Fox, John, Dalal, Prateek, Luna, Evangeline, Klepser, Carolyn, Van Tosh, Andrew, Roberti, Roberto, Pompliano, Jennifer, Horowitz, Steven F.

Journal:

Journal of the American College of Cardiology

Year:

1995

Language:

english

File:

PDF, 311 KB

english, 1995

32

Intramolecular fluorescence enhancement: a continuous assay of Ras farnesyl:protein transferase

Pompliano, David L., Gomez, Robert P., Anthony, Neville J.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 315 KB

english, 1992

33

Engineering a Cell-Free Murein Biosynthetic Pathway: Combinatorial Enzymology in Drug Discovery

Wong, Kenny K., Kuo, David W., Chabin, Renee M., Fournier, Carole, Gegnas, Laura D., Waddell, Sherman T., Marsilio, Frank, Leiting, Barbara, Pompliano, David L.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 63 KB

english, 1998

34

A Phosphinate Inhibitor of the meso -Diaminopimelic Acid-Adding Enzyme (MurE) of Peptidoglycan Biosynthesis

Zeng, Binqi, Wong, Kenny K., Pompliano, David L., Reddy, Sreelatha, Tanner, Martin E.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 92 KB

english, 1998

35

Pseudodipeptide Inhibitors of Protein Farnesyltransferase

deSolms, S. Jane, Deana, Albert A., Giuliani, Elizabeth A., Graham, Samuel L., Kohl, Nancy E., Mosser, Scott D., Oliff, Allen I., Pompliano, David L., Rands, Elaine

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 641 KB

english, 1995

36

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway

Pompliano, David L., Schaber, Michael D., Mosser, Scott D., Omer, Charles A., Shafer, Jules A., Gibbs, Jackson B.

Journal:

Year:

1993

Language:

english

File:

PDF, 851 KB

english, 1993

37

Construction of an enzyme-targeted organophosphonate using immobilized enzyme and whole-cell synthesis

Reimer, L. M., Conley, D. L., Pompliano, D. L., Frost, J. W.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 877 KB

english, 1986

38

Degradation and detoxification of organophosphonates. Cleavage of the carbon-phosphorus bond

Cordeiro, M. L., Pompliano, D. L., Frost, J. W.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 401 KB

english, 1986

39

Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase

Graham, Samuel L., deSolms, S. Jane, Giuliani, Elizabeth A., Kohl, Nancy E., Mosser, Scott D., Oliff, Allen I., Pompliano, David L., Rands, Elaine, Breslin, Michael J.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.05 MB

english, 1994

40

Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis

Reddy, Sreelatha G., Waddell, Sherman T., Kuo, David W., Wong, Kenny K., Pompliano, David L.

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 119 KB

english, 1999

41

N -Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase

deSolms, S. Jane, Giuliani, Elizabeth A., Graham, Samuel L., Koblan, Kenneth S., Kohl, Nancy E., Mosser, Scott D., Oliff, Allen I., Pompliano, David L., Rands, Elaine, Scholz, Thomas H., Wiscount, Cat

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 77 KB

english, 1998

42

Fluorescence detection of alkylphosphonic acids using p-(9-anthroyloxy)phenacyl bromide

Roach, M. C., Ungar, L. W., Zare, R. N., Reimer, L. M., Pompliano, D. L., Frost, J. W.

Journal:

Analytical Chemistry

Year:

1987

Language:

english

File:

PDF, 512 KB

english, 1987

43

Chemical inhibition of dehydroquinate synthase

Myrvold, S., Reimer, L. M., Pompliano, D. L., Frost, J. W.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 872 KB

english, 1989

44

Probing lethal metabolic perturbations in plants with chemical inhibition of dehydroquinate synthase

Pompliano, D. L., Reimer, L. M., Myrvold, S., Frost, J. W.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 1.57 MB

english, 1989

45

Diverse Fragment Clustering and Water Exclusion Identify Protein Hot Spots

Kulp, John L., Kulp, John L., Pompliano, David L., Guarnieri, Frank

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 2.69 MB

english, 2011

46

Development of a Whole-Cell Assay for Peptidoglycan Biosynthesis Inhibitors

Barbosa, M. D. F. S., Yang, G., Fang, J., Kurilla, M. G., Pompliano, D. L.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2002

Language:

english

File:

PDF, 93 KB

english, 2002

47

Oxazolidinones Mechanism of Action: Inhibition of the First Peptide Bond Formation

Patel, U., Yan, Y. P., Hobbs, F. W., Kaczmarczyk, J., Slee, A. M., Pompliano, D. L., Kurilla, M. G., Bobkova, E. V.

Journal:

Journal of Biological Chemistry

Year:

2001

Language:

english

File:

PDF, 669 KB

english, 2001

48

An Electropolishing Technique for Germanium and Silicon

Sullivan, M. V., Klein, D. L., Finne, R. M., Pompliano, L. A., Kolb, G. A.

Journal:

Journal of The Electrochemical Society

Year:

1963

Language:

english

File:

PDF, 1.79 MB

english, 1963

49

Regulated Expression of the Escherichia coli lepB Gene as a Tool for Cellular Testing of Antimicrobial Compounds That Inhibit Signal Peptidase I In Vitro

Barbosa, M. D. F. S., Lin, S., Markwalder, J. A., Mills, J. A., DeVito, J. A., Teleha, C. A., Garlapati, V., Liu, C., Thompson, A., Trainor, G. L., Kurilla, M. G., Pompliano, D. L.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2002

Language:

english

File:

PDF, 207 KB

english, 2002

50

Exons as microgenes?

Seidel, H., Pompliano, D., Knowles,

Journal:

Year:

1992

Language:

english

File:

PDF, 566 KB

english, 1992

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